Board Thread:Questions and Answers/@comment-39718735-20200611060928/@comment-45210418-20200612180351

DIO's blood can bring the dead alive again, the blood of another vampire could possibly have saved DIO, though he was the last remaining vampire seeing that the Stone Mask was destroyed. So it would be impossible to bring him back unless another vampire created by DIO were to come to Egypt and resurrect him with his blood.