Board Thread:Manga Discussion/@comment-33204772-20190109170729/@comment-38952966-20200904174152

DewdOfStuff wrote: he lived after being shot into space, don't know how you get more unkillable than that

Well Kars was removed from the story before Stands were introduced. Kars can regenerate, but it takes time. So Stands with very fast destructive abilities can take him out, like Killer Queen, Cream, The Hand, or D4C.