Nena

Nena is a minor antagonist appearing in Part III: Stardust Crusaders.

History
Nena is an ugly woman from a aristocratic family hired by Dio Brando to kill the Joestar group. Nena used her stand Empress to kill a beautiful young woman and wear her skin to hide her true form. She eventually falls in love with Hol Horse to the point of wanting to marry him. The two become ally and lovers, but Hol Horse actually was just using her love because, like many women around the world, she would be willing to do anything for him.

Stardust Crusaders
Nena is initially portrayed as an ally and lover of Hol Horse, and enemy of the protagonists, but not a true enemy herself. She shows interest in marrying him, but he denies her marriage offer claiming he is a traveler destined to die on the street and couldn't stay with her even though they loved each other. He later reveals to J. Geil that he is with her just because she could be useful in the future, sacrificing her life for him.

After Hol Horse is defeated she eventually comes to his rescue, holding Jean Pierre Polnareff while Hol Horse escapes from Jotaro's team. She then accompanies the group on a bus they take, and it is then that Jean Pierre Polnareff becomes attracted to her while she hides her actual identity as a Stand User, and attacks Joseph Joestar with her stand.

Nena then uses Polnareff´s interest in her to distract him while her stand fights Joseph. After Joseph is able to deal the finishing blow to The Empress, Nena takes the damage and dies, revealing her real form.

Trivia

 * She and Hol Horse were shown to be lovers, just like the tarot cards they represent (The Empress and The Emperor), though it is unknown if Hol Horse knew her true appearance.
 * Nena appears in the OVA, but her role as a antagonist is excluded. As such, she only appears to allow Hol Horse to escape.