Board Thread:Questions and Answers/@comment-44449034-20191118231645/@comment-44942445-20200127220233

Actually, TWOH stopping time for an infinite period of time is a common misconception and is nowhere to be found within the game, anime, manga, scans, etc.

So yes, theoretically he could since as we see, Tusk Act 4 and Golden Experience Requiem hit TWOH (which I mean, you'd say he just negated their power but let me prove you wrong)

Star Platinum then comes in and throws a charged up punch, actually dealing damage to Dio despite the "negating". You could pull a "Dio was just being cocky!" but there is no proof at that, Dio seems like the perfect version of Dio here and I doubt he'd waste a shot at killing Jotaro, he killed the other universe Jotaros as well, why him in particular?

So yes, Made In Heaven actually has a very good chance at defeating TWOH since even if TWOH has some sort of longer time stop which i'm sure he does, Made In Heaven speeds up the flow of time stop to end it quicker, thus making it nearly useless and Pucci would have to be extremely close for even a single hit before the time stop ends due to time acceleration.

Hope this answered the question well for ya! ^-^