Board Thread:Questions and Answers/@comment-45051074-20200723174102/@comment-38952966-20200729031409

I mean, sorta? Pucci doesn't have the buildup behind him that Thanos had, and while he certainly has the highest body count it's arguable as to whether or not Pucci is the strongest main antagonist.

Jotaro is also the only character not originally from Stone Ocean to appear during the Made in Heaven fight, so it's not really like a major crossover event.